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The twelfth season of the American television medical drama Grey's Anatomy was ordered on May 7, 2015, by ABC.
It premiered on September 24, 2015, in the United States on ABC. The twelfth season includes the show's 250th episode, Guess Who's Coming to Dinner, which is the fifth in the season. The season is produced by ABC Studios, in association with ShondaLand Production Company and The Mark Gordon Company; the showrunner being Shonda Rhimes.
| Episode | Title | Directed by | Written by | Air date |
|---|---|---|---|---|
| 1 watch | "Sledgehammer" | Kevin McKidd | Scott M. Gimple & Matthew Negrete | October 11, 2015 |
| 2 watch | "JSS" | Jennifer Lynch | Seth Hoffman | October 18, 2015 |
| 3 watch | "Thank You" | Michael Slovis | Angela Kang | October 25, 2015 |
| 4 watch | "Here's Not Here" | Stephen Williams | Scott M. Gimple | November 1, 2015 |
| 5 watch | "Now" | Avi Youabian | Corey Reed | November 8, 2015 |
| 6 watch | "Always Accountable" | Jeffrey F. January | Heather Bellson | November 15, 2015 |
| 7 watch | "Heads Up" | David Boyd | Channing Powell | November 22, 2015 |
| 8 watch | "Start to Finish" | Michael E. Satrazemis | Matthew Negrete | November 29, 2015 |
